Are herbal supplements safe with prescription medications?

Written by
Thomas Wilson
Reviewed by
Prof. Graham Pierce, Ph.D.Herbal supplements may *dangerously interact* with many prescription drugs through liver enzyme pathways and receptor binding. Chamomile increases the action of blood thinners, which increases the risk of hemorrhage. Similarly, St. John's Wort decreases contraceptive efficacy. Some patients I have seen have been hospitalized as a result of this interaction of common herbs with prescription drugs.
Blood Thinners
- Chamomile/Garlic: Potentiates warfarin increasing bleed risk
- Ginkgo biloba: Inhibits platelet aggregation
- Vitamin K herbs: Counteract anticoagulant effects
- Avoid: 2 weeks before surgery
Antidepressants
- St. John's Wort: Reduces SSRI effectiveness
- Valerian: Enhances sedation dangerously
- SAM-e: May cause serotonin syndrome
- Requires: 8-week washout period
Diabetes Medications
- Bitter melon: Potentiates insulin causing hypoglycemia
- Cinnamon: Enhances drug absorption unpredictably
- Aloe vera: Lowers blood sugar excessively
- Monitor: Glucose levels daily
Protocols save lives. Always disclose all supplements to your doctor and pharmacist before starting any new medications. Pharmacists are aware of metabolic pathways that doctors might overlook. My clinic requires lunches for all supplements at each visit to prevent any dangerous combinations.
Timing is important when using herbs with any prescription medications. It is recommended to space these products at least 4 hours apart to minimize the chance for interaction. Fat-soluble herbs, such as turmeric, may require special consideration regarding meal timing. I create individualized schedules for clients who are taking more than one supplement or medication.
Quality control protocols vary significantly among supplement brands, which increases the risk of contamination. Use third-party tested products with certificates of analysis. Labels of reputable brands show potential interactions. Prescription medications should never be substituted for natural products without the guidance of a medical professional.
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