How does valerian root affect the body?
Written by
Gina Mason
Reviewed by
Prof. Benjamin Murphy, Ph.D.The primary way *valerian root* acts on the body is by stimulating the neurotransmitter GABA acting within the brain. This action reduces the excitement of neural activity, thereby producing sedation in the body that may be helpful in the treatment of insomnia and anxiety. The feeling of relaxation usually sets in within one hour if the proper doses are taken.
The herb also affects serotonin pathways, which are responsible for controlling mood stability. By acting upon these chemical messengers, valerian produces a mild antidepressant effect, as well as its sedative action. This dual action has its basis in the traditional use of this plant to establish a neurotropic derogation for tranquility of the nervous system.
GABA enhancement makes valerian particularly effective for sleep initiation problems. It stills racing thoughts and induces muscle relaxation, which readies the body for our most restorative sleep. The mechanism is not that of prescription sedatives, which aggressively enforce sedation.
Neurological Effects
- GABA modulation: Increases inhibitory neurotransmitter activity
- Serotonin influence: Regulates mood and sleep-wake cycles
- Neural excitation reduction: Lowers stress response intensity
Duration Factors
- Onset time: Effects begin within 60-90 minutes
- Peak concentration: 2-3 hours after ingestion
- Half-life: Active compounds clear in 24-48 hours
Safety Considerations
- Pregnancy contraindication: Potential uterine stimulation
- Liver metabolism: Requires caution with hepatic impairment
- Interaction precautions: Avoid alcohol and sedatives
Biochemical individuality is responsible for your differences in response to valerian. Aspects like activity level of liver enzymes and neurotransmitter balance cause variability among different individuals. Some users experience the drug as strongly sedating, some mildly relaxing, but all users are taking the equivalent dose.
For best results, valerian should be used consistently for 2-4 weeks. The compounds must accumulate in the body to reach safe therapeutic concentrations that maintain the benefits achieved with regular use. A short-term use will only provide relief from symptoms, but not with the same effects as regular dosing.
Read the full article: Valerian Root Effects: Benefits and Risks Explained
